Tag: ovarian cancer

Pharmacology News Digest, July 22nd 2018

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Paclitaxel (Taxol®, Abraxane®) – Taxane Antineoplastic

Paclitaxel is a taxane-class cytotoxic chemotherapeutic agent for cancer treatment.

Paclitaxel inhibits microtubule depolymerization in dividing cells, blocking the metaphase-anaphase transition and eventually leading to apoptosis.  Lack of specificity for tissue type have made this drug a mainstay of treatment for a variety of malignancies, especially those of the ovary, breast, and lung, while also underlying its significant off-target toxicity.

Patients should be pre-treated with corticosteroids and anti-histamines due to a relatively high risk of severe hypersensitivity reactions during infusion.



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