Tag: opioid

Pharmacology Digest, July 29th, 2018

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Pharmacology News Round-Up: June 28th, 2018

Continue reading “Pharmacology News Round-Up: June 28th, 2018”

NSAIDs > Opioids in Acute Dental Pain – The Journal of the American Dental Association

An overview of systematic reviews looking at acute pain relief in dental patients, primarily following third-molar extractions, found non-opioid medications were associated with longer lasting and more effective pain relief than opioids and opioid drug combinations.

While oxycodone was noted to have a duration of pain relief comparable to acetaminophen or the NSAID diflunisal, it was also associated with a higher frequency of adverse outcomes.

The review authors suggest that NSAIDs (e.g., ibuprofen) with or without acetaminophen provide the most optimal balance of benefits and risks for the majority of dental pain patients.

 

Source: Benefits and harms associated with analgesic medications used in the management of acute dental pain – The Journal of the American Dental Association

Nigeria bans cough syrup with codeine after addiction outcry – BBC News

Widespread consumption of codeine-containing cough syrup has led to increased rates of opioid addiction in Nigerian youth. A pharmaceutical executive with Emzor was recorded discussing his participation in the illicit marketing, and sale of the drug and cough syrup containing codeine has subsequently been banned by the Nigerian government.

Codeine clinical information

 

Source: Nigeria bans cough syrup with codeine after addiction outcry – BBC News

Methadone (Methadose®, Dolophine®) – Synthetic Opioid

Methadone is a synthetic μ-opioid receptor agonist prescribed for the treatment of opioid dependence and withdrawal.  It is also used in severe pain conditions at lower doses.

Methadone has a longer half-life and fewer euphoric effects than morphine and other opioids, but still carries a dose-dependent risk of the toxicities associated with this class of drugs.  Sedation, dizziness, and headache are common side effects and incorrect dosing or abuse can result in profound sedation, respiratory depression, and death.

methadone

Citations

  1. Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2017 Nov 8. doi: 10.1093/nar/gkx1037
  2. Epocrates Rx Online [Internet database]. San Mateo (CA): Epocrates, Inc. 2003. Retrieved at mobile.epocrates.com. Web-based; continuous content updates. Accessed 2018 April 24.
  3. “Prescription Prices, Coupons & Pharmacy Information – GoodRx.” Prescription Prices, Coupons & Pharmacy Information – GoodRx, www.goodrx.com