Tag: basal cell carcinoma

Common Blood Pressure Med HCTZ Associated With Increased Skin Cancer Risk | JAAD

Key Points

  • >78,000 patients with BCC (basal cell carcinoma) or SCC (cutaneous squamous cell carcinoma)
  • 1/11 SCC cases attributable to HCTZ (hydrochlorothiazide), assuming causation
  • 7-fold increased risk of SCC lip cancer w/ 200,000 mg cumulative HCTZ
  • Dose-response pattern
  • Highest risk increase in younger patients (<50y)


  • HCTZ is diuretic-class antihypertensive
  • Known skin-sensitizer
  • Non-melanoma skin cancers most common human malignancy
  • >3,000 deaths/year from NMSC


  • Observational, Case-Control

Source: Hydrochlorothiazide use and risk of nonmelanoma skin cancer: A nationwide case-control study from Denmark – Journal of the American Academy of Dermatology