Alprazolam (Xanax®, Niravam®)

Alprazolam is a short-acting benzodiazepine medication used in the treatment of anxiety disorders.  It acts as a positive allosteric modulator of synaptic GABAA receptors, increasing neuronal hyperpolarization and CNS depressant effects.  Alprazolam is the only benzodiazepine with significant antidepressant efficacy.

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Lidocaine HCl (Xylocaine®, Zingo®, Lidoderm®, RectiCare®, LMX®, Akten®)

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Bupropion (Wellbutrin®, Forvivo®, Zyban®, Aplenzin®)

Overview

Bupropion is an aminoketone antidepressant medication indicated for the treatment of major depressive disorder and to reduce withdrawal symptoms during smoking cessation. Continue reading “Bupropion (Wellbutrin®, Forvivo®, Zyban®, Aplenzin®)”

Arthritis Drug Tofacitinib Approved for Severe Ulcerative Colitis | FDA

The US FDA has approved tofacitinib (Xeljanz, Pfizer) for the treatment of moderate-severe ulcerative colitis (UC).

Tofacitinib

  • Janus kinase inhibitor (blocks STAT transcription factor activation and inflammatory signaling)
  • First oral agent approved for chronic use in UC
  • 10 mg tofacitinib PO BID induced remission in 17-18% of patients (vs. 8.2% placebo) after 8 weeks
  • Of patients that responded after 8 week trial, 40.6% who continued 10-mg tofacitinib for 52 weeks achieved sustained remission (versus 11.1% placebo)
  • Adverse events (common):  arthralgia, diarrhea, elevated cholesterol, headache, shingles, rash, and upper respiratory infection
  • Adverse events (severe): malignancy (e.g., lymphoma), serious opportunistic infections (FDA black-box warnings)

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Fluticasone Propionate vs. Fluticasone Furoate: What’s the Difference?

Fluticasone Propionate and Fluticasone Furoate: Ester Cousins

Fluticasone propionate (FP) and fluticasone fuorate (FF) are both synthetic glucocorticoid drugs used in the prevention of asthma exacerbations and for the treatment of allergy symptoms and rhinitis. Continue reading “Fluticasone Propionate vs. Fluticasone Furoate: What’s the Difference?”

Fluticasone Furoate (Flonase Sensimist®, Arnuity Ellipta®)

Overview

Fluticasone furoate is a synthetic corticosteroid with clinical applications in the treatment of asthma and allergy symptoms.  Continue reading “Fluticasone Furoate (Flonase Sensimist®, Arnuity Ellipta®)”

Fluticasone Propionate (Flonase Allergy Relief®, Flovent®, ArmonAir RespiClick® Cutivate®)

Overview

Fluticasone propionate is a synthetic corticosteroid with clinical applications in the treatment of asthma, allergy symptoms, non-allergic rhinitis, and dermatologic conditions.  Continue reading “Fluticasone Propionate (Flonase Allergy Relief®, Flovent®, ArmonAir RespiClick® Cutivate®)”

Anti-IL-1β Therapy For Genetic Fever Syndromes Eliminates Flares in Nearly Half of Patients | NEJM

Study

  • Clinical Trial: CLUSTER
  • Authors: Benedetti, Penades et al
  • Journal: New England Journal of Medicine
  • Date: May 17th, 2018

Conclusions

  • Subcutaneous canakinumab, an anti-IL-1β antibody, eliminated flares in 23-53% of patients with one of three autoinflammatory fever syndromes (FMF, MKD, TRAPS) for up to 40 weeks
  • IL-1β common mediator in FMF, MKD, TRAPS pathogenesis
  • Increased risk of infection w/ canakinumab use

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