NSAIDs > Opioids in Acute Dental Pain – The Journal of the American Dental Association

An overview of systematic reviews looking at acute pain relief in dental patients, primarily following third-molar extractions, found non-opioid medications were associated with longer lasting and more effective pain relief than opioids and opioid drug combinations.

While oxycodone was noted to have a duration of pain relief comparable to acetaminophen or the NSAID diflunisal, it was also associated with a higher frequency of adverse outcomes.

The review authors suggest that NSAIDs (e.g., ibuprofen) with or without acetaminophen provide the most optimal balance of benefits and risks for the majority of dental pain patients.


Source: Benefits and harms associated with analgesic medications used in the management of acute dental pain – The Journal of the American Dental Association