Dabigatran Etexilate (Pradaxa®)


Dabigatran etexilate is a direct-acting oral anticoagulant used in the prevention of thromboembolism in atrial fibrillation and in the prevention and treatment of deep venous thrombosis and pulmonary embolism. Dabigatran etexilate is a pro-drug converted via plasma and hepatic esterases to dabigatran, which directly inhibits the enzyme thrombin.  Thrombin catalyzes the conversion of fibrinogen to fibrin and fibrin-mediated platelet aggregation.

Dabigatran should not be prescribed in actively bleeding patients or patients with mechanical heart valves.  Dabigatran toxicity may involve significant hemorrhage and is partially reversible through the reversal agent idarucizumab (Praxbind®).




  1. Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2017 Nov 8. doi: 10.1093/nar/gkx1037
  2. Epocrates Rx Online [Internet database]. San Mateo (CA): Epocrates, Inc. 2003. Retrieved at mobile.epocrates.com. Web-based; continuous content updates. Accessed 2018 April 29.
  3. “Prescription Prices, Coupons & Pharmacy Information – GoodRx.” Prescription Prices, Coupons & Pharmacy Information – GoodRxhttp://www.goodrx.com
  4. “DailyMed.” U.S. National Library of Medicine, National Institutes of Health, dailymed.nlm.nih.gov/dailymed/.