Clomiphene (Clomid®, Serophene®) – Selective Estrogen Receptor Modulator

Clomiphene (Clomid®, Serophene®) is a selective estrogen receptor modulator (SERM) drug FDA-approved for the treatment of infertility caused by anovulation.  The drug targets the estrogen receptor and has both agonist and antagonistic properties depending on tissue type.  Competition with estrogens results in gonadotropin release by the anterior pituitary gland, increased sex hormone production, and stimulation of follicle release by the ovaries.

Clomiphene has also shown efficacy in treatment of male infertility via induction of spermatogenesis and is sometimes prescribed off-label for this purpose.

clomiphene

Citations

  1. Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2017 Nov 8. doi: 10.1093/nar/gkx1037
  2. Epocrates Rx Online [Internet database]. San Mateo (CA): Epocrates, Inc. 2003. Retrieved at mobile.epocrates.com. Web-based; continuous content updates. Accessed 2018 April 27.
  3. “Prescription Prices, Coupons & Pharmacy Information – GoodRx.” Prescription Prices, Coupons & Pharmacy Information – GoodRxhttp://www.goodrx.com
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