Celecoxib (Celebrex®) – Non-Steroidal Anti-Flammatory

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain and certain inflammatory conditions.  It is a selective inhibitor of cyclooxygenase-2 (COX2), blocking PGH-2 and downstream PGE-2 synthesis.  Decreased prostaglandin production impairs pro-inflammatory pathways and leads to decreased pain sensation.

Other COX-2-specific inhibitors have been withdrawn from the market due to concerns about thromboembolic risk.  The United States FDA recently determined that the available evidence does not conclusively demonstrate an elevated thromboembolic risk with celecoxib use relative to other NSAIDS.

celecoxib

Citations

  1. Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2017 Nov 8. doi: 10.1093/nar/gkx1037
  2. Epocrates Rx Online [Internet database]. San Mateo (CA): Epocrates, Inc. 2003. Retrieved at mobile.epocrates.com. Web-based; continuous content updates. Accessed 2018 April 26.
  3. “Prescription Prices, Coupons & Pharmacy Information – GoodRx.” Prescription Prices, Coupons & Pharmacy Information – GoodRx, www.goodrx.com
  4. Stein, Rob. “FDA Panel Affirms Safety Of Painkiller Celebrex.” NPR, NPR, 25 Apr. 2018, www.npr.org/sections/health-shots/2018/04/25/605226604/fda-panel-affirms-safety-of-painkiller-celebrex.
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