Category: Seizure

Lidocaine HCl (Xylocaine®, Zingo®, Lidoderm®, RectiCare®, LMX®, Akten®)

Continue reading “Lidocaine HCl (Xylocaine®, Zingo®, Lidoderm®, RectiCare®, LMX®, Akten®)”

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Gabapentin (Neurontin®, Gralise®)

Overview

Gabapentin is a neuronal calcium channel blocker and GABA synthesis/degradation modulator used in the treatment of epilepsy involving non-generalizing partial seizures, as well as post-herpetic neuralgia (PHN).  Continue reading “Gabapentin (Neurontin®, Gralise®)”

Phenytoin (Dilantin®, Phenytek®) – Voltage-Gated Sodium Channel Blocker

Phenytoin is a voltage-gated sodium channel blocker commonly prescribed as an anticonvulsant.  Phenytoin or its prodrug fosphenytoin are given intravenously in the treatment of status epilepticus or in oral formulations as control treatment in seizure disorders.  Fosphenytoin may carry a lower risk of causing an injection site reaction than phenytoin.

Phenytoin decreases neuronal membrane excitability in the motor cortex and other cortical domains by blocking voltage-gated sodium channel proteins and stabilizing neuronal membranes against spurious depolarization during epileptiform electrical activity.

phenytoin

 

Citations

  1. Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2017 Nov 8. doi: 10.1093/nar/gkx1037
  2. Epocrates Rx Online [Internet database]. San Mateo (CA): Epocrates, Inc. 2003. Retrieved at mobile.epocrates.com. Web-based; continuous content updates. Accessed 2018 April 20.