Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and non-selective cyclooxygenase inhibitor indicated for the treatment of mild-moderate pain, fever, and arthritis. Its analgesic, antipyretic, and anti-inflammatory properties are thought to be mediated through inhibition of the cyclooxygenase-2 (COX-2) enzyme. COX-2 is upregulated by cells during the inflammatory response, resulting in increased production of PGE2 and leading to tissue inflammation, fluid extravasation, pyrexia, pain, and vasodilation. Inhibition of prostaglandin synthesis by ibuprofen blocks inflammatory signaling pathways and decreases pain and body temperature.
Overview Combination hydrocodone/acetaminophen is an analgesic medication prescribed for the treatment of acute and chronic pain. Hydrocodone activates […]
Gabapentin is a neuronal calcium channel blocker and GABA synthesis/degradation modulator used in the treatment of epilepsy involving non-generalizing partial seizures, as well as post-herpetic neuralgia (PHN).
Codeine is an opioid drug indicated for mild-to-moderate pain. It functions as a selective μ-opioid receptor agonist and […]
Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain and certain inflammatory conditions. It is a […]
Methadone is a synthetic μ-opioid receptor agonist prescribed for the treatment of opioid dependence and withdrawal. It is […]