Category: Autoimmune

Fluticasone Furoate (Flonase Sensimist®, Arnuity Ellipta®)

Overview

Fluticasone furoate is a synthetic corticosteroid with clinical applications in the treatment of asthma and allergy symptoms.  Continue reading “Fluticasone Furoate (Flonase Sensimist®, Arnuity Ellipta®)”

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Fluticasone Propionate (Flonase Allergy Relief®, Flovent®, ArmonAir RespiClick® Cutivate®)

Overview

Fluticasone propionate is a synthetic corticosteroid with clinical applications in the treatment of asthma, allergy symptoms, non-allergic rhinitis, and dermatologic conditions.  Continue reading “Fluticasone Propionate (Flonase Allergy Relief®, Flovent®, ArmonAir RespiClick® Cutivate®)”

Ibuprofen (Motrin®, Caldolor®, Advil®)

Overview

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and non-selective cyclooxygenase inhibitor indicated for the treatment of mild-moderate pain, fever, and arthritis.  Its analgesic, antipyretic, and anti-inflammatory properties are thought to be mediated through inhibition of the cyclooxygenase-2 (COX-2) enzyme.  COX-2 is upregulated by cells during the inflammatory response, resulting in increased production of PGE2 and leading to tissue inflammation, fluid extravasation, pyrexia, pain, and vasodilation.  Inhibition of prostaglandin synthesis by ibuprofen blocks inflammatory signaling pathways and decreases pain and body temperature. Continue reading “Ibuprofen (Motrin®, Caldolor®, Advil®)”

Anakinra (Kineret®)

Anakinra is a recombinant human IL-1 receptor antagonist approved as a disease modifying reagent for moderate-to-severe rheumatoid arthritis (RA) and neonatal-onset multisystem inflammatory disease (NOMID).  Anakinra inhibits the IL-1 Type I receptor with the same mechanism as the endogenous IL-1 antagonist IL-1RA.

Inhibition of the IL-1 receptor in cartilage results in decreased cartilage degradation and bone resorption and slowing of the progression of RA.  Off-target anticytokine effects lower infection threshold and may result in hematological cytopenias, upper respiratory infection or more severe infection.

 

anakinra

Citations

  1. Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2017 Nov 8. doi: 10.1093/nar/gkx1037
  2. Epocrates Rx Online [Internet database]. San Mateo (CA): Epocrates, Inc. 2003. Retrieved at mobile.epocrates.com. Web-based; continuous content updates. Accessed 2018 April 29.
  3. “Prescription Prices, Coupons & Pharmacy Information – GoodRx.” Prescription Prices, Coupons & Pharmacy Information – GoodRxhttp://www.goodrx.com
  4. “DailyMed.” U.S. National Library of Medicine, National Institutes of Health, dailymed.nlm.nih.gov/dailymed/.

 

Celecoxib (Celebrex®) – Non-Steroidal Anti-Flammatory

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain and certain inflammatory conditions.  It is a selective inhibitor of cyclooxygenase-2 (COX2), blocking PGH-2 and downstream PGE-2 synthesis.  Decreased prostaglandin production impairs pro-inflammatory pathways and leads to decreased pain sensation.

Other COX-2-specific inhibitors have been withdrawn from the market due to concerns about thromboembolic risk.  The United States FDA recently determined that the available evidence does not conclusively demonstrate an elevated thromboembolic risk with celecoxib use relative to other NSAIDS.

celecoxib

Citations

  1. Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2017 Nov 8. doi: 10.1093/nar/gkx1037
  2. Epocrates Rx Online [Internet database]. San Mateo (CA): Epocrates, Inc. 2003. Retrieved at mobile.epocrates.com. Web-based; continuous content updates. Accessed 2018 April 26.
  3. “Prescription Prices, Coupons & Pharmacy Information – GoodRx.” Prescription Prices, Coupons & Pharmacy Information – GoodRx, www.goodrx.com
  4. Stein, Rob. “FDA Panel Affirms Safety Of Painkiller Celebrex.” NPR, NPR, 25 Apr. 2018, www.npr.org/sections/health-shots/2018/04/25/605226604/fda-panel-affirms-safety-of-painkiller-celebrex.