The US FDA has approved the antihelminthic drug moxidectin (developed by Medicines Development for Global Health) for the treatment of onchocerciasis.¹ Merck’s ivermectin, developed in the late 1970s, is the only other pharmaceutical agent approved for treating […]
This week’s clinical pharmacology highlights include a new treatment for river blindness, further success for JAK inhibitors in inflammatory diseases, and the finding that more patients are taking medications associated with depressive symptoms. ———————————————————————– FDA Approvals […]
Overview Alprazolam is a short-acting benzodiazepine medication used in the treatment of anxiety disorders. It acts as a positive allosteric modulator of synaptic GABAA receptors, increasing neuronal hyperpolarization and CNS depressant effects. Alprazolam is the only […]
Overview Lidocaine is a sodium channel blocker used as an anesthetic agent and in the treatment of ventricular arrhythmias. It inhibits Na+ conduction through voltage-gated sodium channels in the membranes of neurons and cardiac myocytes, inhibiting […]
The US FDA has approved the JAK inhibitor baricitinib (Olumiant, Lilly) for the treatment of moderate to severe rheumatoid arthritis.
The US FDA has approved an amlodipine besylate and celecoxib combination pill (Consensi®, Kitov) for the treatment of patients with hypertension and osteoarthritis-related pain.
Overview Bupropion is an aminoketone antidepressant medication indicated for the treatment of major depressive disorder and to reduce withdrawal symptoms during smoking cessation.
The US FDA has approved tofacitinib (Xeljanz, Pfizer) for the treatment of moderate-severe ulcerative colitis (UC). Tofacitinib Janus kinase inhibitor (blocks STAT transcription factor activation and inflammatory signaling) First oral agent approved for chronic use in […]
Fluticasone Propionate and Fluticasone Furoate: Ester Cousins Fluticasone propionate (FP) and fluticasone fuorate (FF) are both synthetic glucocorticoid drugs used in the prevention of asthma exacerbations and for the treatment of allergy symptoms and rhinitis.
Overview Fluticasone furoate is a synthetic corticosteroid with clinical applications in the treatment of asthma and allergy symptoms.