Anakinra (Kineret®)

Anakinra is a recombinant human IL-1 receptor antagonist approved as a disease modifying reagent for moderate-to-severe rheumatoid arthritis (RA) and neonatal-onset multisystem inflammatory disease (NOMID).  Anakinra inhibits the IL-1 Type I receptor with the same mechanism as the endogenous IL-1 antagonist IL-1RA.

Inhibition of the IL-1 receptor in cartilage results in decreased cartilage degradation and bone resorption and slowing of the progression of RA.  Off-target anticytokine effects lower infection threshold and may result in hematological cytopenias, upper respiratory infection or more severe infection.




  1. Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2017 Nov 8. doi: 10.1093/nar/gkx1037
  2. Epocrates Rx Online [Internet database]. San Mateo (CA): Epocrates, Inc. 2003. Retrieved at Web-based; continuous content updates. Accessed 2018 April 29.
  3. “Prescription Prices, Coupons & Pharmacy Information – GoodRx.” Prescription Prices, Coupons & Pharmacy Information – GoodRx
  4. “DailyMed.” U.S. National Library of Medicine, National Institutes of Health,