Anakinra (Kineret®) – Recombinant IL-1 Receptor Antagonist

Anakinra is a recombinant human IL-1 receptor antagonist approved as a disease modifying reagent for moderate-to-severe rheumatoid arthritis (RA) and neonatal-onset multisystem inflammatory disease (NOMID).  Anakinra inhibits the IL-1 Type I receptor with the same mechanism as the endogenous IL-1 antagonist IL-1RA.

Inhibition of the IL-1 receptor in cartilage results in decreased cartilage degradation and bone resorption and slowing of the progression of RA.  Off-target anticytokine effects lower infection threshold and may result in hematological cytopenias, upper respiratory infection or more severe infection.




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