Amlodipine (Norvasc®)


Amlodipine is a dihydropyridine calcium channel blocker used in the treatment of hypertension and coronary artery disease.  It selectively inhibits vascular L-type calcium channels, decreasing calcium influx into smooth muscle cells and preventing calcium-mediated vasoconstriction.  In stable and vasospastic angina, daily amlodipine dosing reduced the number of anginal attacks, and patients with angiographically-documented coronary artery disease were less likely require hospitalization and revascularization when treated with the drug.

Most patients experience few adverse effects from amlodopine; the most common concern in clinical trials was peripheral edema.  Rarely, patients may experience paradoxical worsening of an acute coronary syndrome after receiving amlodipine.

Amlodipine (or other dihydropyridines like nifedipine) are also sometimes used off-label to treat Raynaud phenomenon.

In Plain English

Calcium causes your blood vessels to constrict and raises your blood pressure.  Amlodipine alters the flow of calcium and reduces constriction in your arteries and veins.

Clinical Considerations


Figure 1. Amlodipine clinical considerations at a glance


Evidence Basis


Amlodipine In the News



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